A voxel-wise logistic regression model that is fitted independently for each voxel in the FLAIR image. Images were transformed to the MNI-152 standard space for training and at test time the parameter maps were warped to the subject space.

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Knight, J., Taylor, G. W., & Khademi, A. (2018). Voxel-Wise Logistic Regression and Leave-One-Source-Out Cross Validation for white matter hyperintensity segmentation. Magnetic resonance imaging54, 119-136.