MRI parameters

The used MRI sequence parameters follow below.

UMC Utrecht – 3 T Philips Achieva: 3D T1-weighted sequence (192 slices, voxel size: 1.00×1.00×1.00 mm3, TR/TE: 7.9/4.5 ms), 2D FLAIR sequence (48 slices, voxel size: 0.96×0.95×3.00 mm3, TR/TE/TI: 11000/125/2800 ms)

NUHS Singapore – 3 T Siemens TrioTim: 3D T1-weighted sequence (voxel size: 1.00×1.00×1.00 mm3, TR/TE/TI: 2300/1.9/900 ms), 2D FLAIR sequence (voxel size: 1.0×1.0x3.00 mm3, TR/TE/TI: 9000/82/2500 ms)

VU Amsterdam – 3 T GE Signa HDxt: 3D T1-weighted sequence (176 slices, voxel size: 0.94×0.94×1.00 mm3, TR/TE: 7.8/3.0 ms), 3D FLAIR sequence (132 slices, voxel size: 0.98×0.98×1.2 mm3, TR/TE/TI: 8000/126/2340)

VU Amsterdam – 3 T Philips Ingenuity: 3D T1-weighted sequence (180 slices, voxel size: 0.87×0.87×1.00 mm3, TR/TE: 9.9/4.6 ms, 3D FLAIR sequence (321 slices, voxel size: 1.04×1.04×0.56 mm3, TR/TE/TI: 4800/279/1650 ms)

VU Amsterdam – 1.5 T GE Signa HDxt: 3D T1-weighted sequence (172 slices, voxel size: 0.98×0.98×1.50 mm3, Repetition Time (TR)/Echo Time (TE): 12.3/5.2 ms), 3D FLAIR sequence (128 slices, voxel size: 1.21×1.21×1.30 mm3, TR/TE/Inversion Time (TI): 6500/117/1987 ms)

In case a 3D FLAIR image was acquired, it was resampled to a slice-thickness of 3.00 mm.